Historical knowledge and contemporary experience suggest that One Health, with its 200-year legacy, transcended being a static, fashionable term during its modern period (2004–2016), evolving into Contemporary One Health Thinking over the past decade. During the Anthropocene’s last half-century, humanity has confronted serious health challenges, while the synergy of ecological, anthropogenic, and microbial factors has transformed Anthropocenic Threats into a formidable storm.